의약품 원료 DIET 합성 중 H2O2를 이용한 붕소제거 반응공정에서의 폭주반응 위험성 평가 pharmaceutical Ingredient, boron removal reaction, reaction calorimeter, risk, runaway reaction | 2021.06.24 | ||
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저자: 김원성, 이근원
(원문 바로가기) ABSTRACT In the Active Pharmaceutical Ingredient(API) manufacturing company, since the product is produced by the chemical reaction, fire and explosion are frequently occurred in the process of inputting the raw powder as the chemical reaction stage. There are not many studies on safety measures through analysis of cause of accident in the actual chemical reaction stage. In this study, we investigated the heat flow in the boron removal reaction process to investigate the risk in the chemical reaction stage. The study reaction process was performed by using the reaction calorimeter for the products synthesized at the actual raw material in pharmaceutical factory. The risk was estimated by comparing the maximum temperature of the synthesis reaction, which can generate heat due to the failure of cooling in the actual manufacturing process, and the technical temperature. These results are applied to commercial manufacturing sites and safety measures to control the risk of runaway reaction due to reaction heat are suggested. Keywords pharmaceutical Ingredient, boron removal reaction, reaction calorimeter, risk, runaway reaction |
이전글 | 안전보건표지의 관리 실태와 이해 용이성 |
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다음글 | 작업환경측정 지정기관의 분석실 현황 및 분석결과의 신뢰성에 영향을 주는 요인 |