| Chemical toxicity by sex diferences: a literature review of 2019？2023 studies | 2024.12.31 | ||
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저자: Kyung？Taek Rim
Abstract
Objective and methods While diferences in cancer incidence between the two sexes/genders are often explained by diferences in environmental exposure or the infuence of sex hormones, there is little research on intrinsic diferences in sensitivity to chemical carcinogens. This review summarizes the literature obtained by searching the papers used in most research for the necessary data, including PubMed, specifcally for the last 5 years 2019–2023. The search was performed using the key terms “chemical”, “toxicity”, “gender”, and “sex diferences”, and “cancer” or “disease”. Results and conclusion Based on the literature data, over 80 potential articles were found. A total of 28 papers that satisfed the inclusion criteria were selected for detailed analysis. While some sex diferences in cancer occur through the action of circulating sex hormones, other sex diferences are unrelated to estrogen, testosterone, or progesterone levels. Globally, sex diferences in tumor incidence and mortality are evident across a wide range of age groups.
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